Fig. 9
A Representative microscopic pictures of Masson`s trichrome-stained colorectal tissues from control, dimethylhydrazine (DMH), DMH + artemisinin (DMH + ART), and DMH + artemisinin-loaded polylactic acid nanoparticles (DMH + ART-PLA NPs) groups showing the degree of mucosal fibrosis. Colorectal tissue of untreated DMH group revealing bluish mucosal fibrosis (black arrows). Colorectal tissue of DMH + ART group showing decreased bluish mucosal fibrosis (black arrows). Colorectal tissue of DMH + ART-PLA NPs group showing mild bluish mucosal fibrosis (black arrows). Magnifications are × 100; bar = 100 µm. B Bar chart representing changes in fibrosis area % in colorectal tissue. All the values are expressed as mean ± SEM (n = 10). #, significant as compared to control groups p < 0.05, ! means significant as compared to control groups and DMH group p < 0.05, and $ means significant as compared to DMH and DMH + ART groups p < 0.05