Fig. 7

Microscopic findings of H&E-stained colorectal tissues showing different types of colorectal tumors in all experimental groups including: small polypoid tubular adenoma (arrow) (A), pedunculated tubular adenoma (arrow) (B), sessile tubular adenoma (arrow), the base of the adenoma shows normal colonic mucosa (arrowhead) (C), tubulovillous adenoma (arrow) (D), sessile serrated (arrow) (E), advanced moderately differentiated adenocarcinomas in mucosa starts to infiltrate submucosa (arrow) (F), advanced moderately differentiated adenocarcinomas (arrow) in mucosa and deeply infiltrating submucosa (G), advanced moderately differentiated adenocarcinomas deeply infiltrating submucosa (arrow) with intact mucosa (arrowhead) (H), invasive poorly differentiated adenocarcinoma (arrow) reaching muscular layer and serosa (I), invasive mucinous adenocarcinoma (arrow) reaching muscular layer in some points (J) and signet ring adenocarcinoma (arrow) infiltrating submucosa (K and L). Magnifications are 40×, bar = 200, ×100, bar = 100 and 400×, bar = 50