Fig. 4

Enhanced multimodal image-guided phototherapy using liposomal formulations of NIR dyes and photosensitizers. In this approach, liposomes containing the photosensitizer chlorophyll derivative pyropheophorbide acid (PPa) and the NIR dye ICG are used to perform PDT and PTT in breast cancer cells. The nanoliposomes also entrapped PFOB, which exhibits high oxygen affinity and loading capacity, leading to the elimination of tumor hypoxia and enhanced PDT. The resulting formulation exhibits promising contrast imaging features when imaged via CT and fluorescence imaging. (Sheng et al. 2018). License code: 5544110712266)