Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology

Table 4 Recent examples in CAF subtype-targeting nanomaterials

CAF subtype	Marker	Nanomaterial type	Tumor model	Targeting strategy	Outcome	Refs.
myCAFs	α-SMA	α-SMA-targeted nanoparticle	Pancreatic, breast	ECM disruption	Increased immune cell infiltration and reduced ECM stiffness	Roy Chaudhuri et al. (2016); Zhang et al. (2024f)
iCAFs	FAP	FAP-targeted liposomes	Melanoma, GI cancer	Cytokine silencing	Reduced immunosuppression and enhanced T-cell response	Ran and Chen (2024); Agorku et al. (2024); Picard et al. (2023)
apCAFs	MHC-II	MHC-II-targeted nanoparticle	Ovarian	Immune modulation	Increased T-cell activation and reduced T-cell anergy	Noureddine et al. (2023; Marwedel et al. (2024)

ISSN: 1868-6966