Table 2 Advantages and limitations of nanomaterials for CAF targeting
From: Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts
Nanomaterial type | Examples | Unique properties and advantages | Limitations |
|---|---|---|---|
Organic | Liposomes, PLGA NPs | High biocompatibility, versatile drug/gene delivery | Limited imaging and lower physical stability |
Inorganic | Iron oxide NPs, AuNPs, QDs | Magnetic and optical properties for targeted therapy and imaging | Potential toxicity, organ accumulation, complex clearance |
Hybrid | Liposome-AuNPs, PLGA-coated Fe NPs | Enhanced stability, combined drug delivery and imaging (theranostics) | Complex synthesis, regulatory hurdles |