Fig. 6
a Western blot analysis of P-gp, Bcl-2, and Caspase-3 protein expression levels in HepG2 cells under different treatment conditions. b Heatmap of the quantitative analysis of the Western blot results shown in Fig. 6a. c Western blot analysis of cIAP1 and PARP-1 protein expression levels in HepG2 cells under different treatment conditions. d Heatmap of the quantitative analysis of the Western blot results shown in Fig. 6c. Experimental setup: blank control group treated with PBS; miR-122 group at a concentration of 270 nmol L−1; DOX group at a concentration of 50 μg mL−1; Fe-miR-NC/DOX nanoparticles group with miR-NC at 270 nmol L−1 and DOX at 50 μg mL−1; Fe-miR-122/DOX nanoparticles group with miR-122 at 270 nmol L−1 and DOX at 50 μg mL−1. It should be noted that in SDS-PAGE gel electrophoresis analysis, P-gp and cIAP1 were run on the same gel, resulting in β-actin being present as a single band