Scheme 1.

Synthesis of Pt-8AQ and loading on MSCs. Reagents and Conditions: (i) K₂PtCl₄, H₂O/HCl 6 M (8 equiv.), reflux for 18 h; (ii) Alkyl-imidazole, DMF, 55 °C 18 h; (iii) DMEM, final concentration of 12.5 µM, 1 h at 37 °C