Fig. 1

Schematic illustration of PD1-NP-PDL1 designed for immunotherapy of colon cancer. Thio-modified PD-1 and PD-L1 aptamers were jointly conjugated to albumin nanoparticles to construct PD1-NP-PDL1, which could bind with PD-1 expressed on T cells and PD-L1 expressed on tumor cells