Fig. 2
From: Application of tumor microparticles in tumor prevention and treatment
The schematic diagram of mechanism by which T-MPs activated DCs (Ma et al. 2018). a T-MPs increased DC lysosomal pH, causing Ca2+ release through lysosomal Ca2+ channel Mcoln2. Ca2+ induced the activation of TFEB, thus promoting the expression of CD80/86; b mature DCs enable full activation of tumor-specific CD8+ T cells