Fig. 4

Gold nanoparticle uptake in monolayer and spheroid. a, b Uptake of gold nanoparticles in a monolayer and b spheroids of HeLa and LNCaP with and without docetaxel. Error bars are the 95% confidence interval from three independent experiments. c, e Confocal images of a monolayer of HeLa with gold nanoparticles, c without and e with docetaxel. d, f Confocal images of spheroids of HeLa with gold nanoparticles, d without and f with docetaxel. Gold nanoparticles and nuclei are marked in red and blue, respectively. Scale bars are 25 \(\upmu\)m. ns indicates no significance, * indicates 0.01 < p < 0.05, ** indicates 0.001 < p < 0.01, *** indicates 0.0001 < p < 0.001