Scheme 1

a Illustration of EGFR-TKI loaded NPs fabrication by FNP and their performance on the therapy of NSCLC tumor. Streams containing TKIs and polymer stabilizer are mixed on MIVM (multiple inlet vortex mixer) and construct well-defined EGFR-TKI loaded NPs. b Chemical structures of drugs including afatinib, cisplatin and gefitinib, and the polymer stabilizer Dextran-b-PLA decorated with FA