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Fig. 13 | Cancer Nanotechnology

Fig. 13

From: Co-axial electrospraying of injectable multi-cancer drugs nanocapsules with polymer shells for targeting aggressive breast cancers

Fig. 13

Intratumoral administration of encapsulated paclitaxel with GW2558 did not alter the metastatic potential of 4T1 tumor cells. Mice were killed 3 days after the last dose injection to check the metastatic colonization of luciferase expressing 4T1 tumor cells. a, b IP-injection of naked paclitaxel decrease the tumor weight. c Although encapsulated paclitaxel (PCL-Pac + GW) showed a tendency towards increased weight, no significant difference were detected for spleen weight between groups. d, e While only micro metastases were observed in the lungs of naked pac-treated animals, two of animals in encapsulated pac-treated group showed macro-metastasis in their lungs. Yet, signal intensity of luciferase was not significantly different between groups. Results are presented as mean ± SD (three mice in each group)

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Cancer Nanotechnology

ISSN: 1868-6966

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