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Fig. 6 | Cancer Nanotechnology

Fig. 6

From: Inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and inhibits progression, attenuates doxorubicin resistance in breast cancer

Fig. 6

ABCC9-repressed ferroptosis of BC cells is reversed by ZON. A, B The MDA-MB-231/Dox and MDA-MB-468/Dox cells were treated with ZON. A The mRNA expression of ABCC9 was detected by qPCR. B The protein expression of ABCC9 was analyzed by Western blot analysis. C The MDA-MB-231/Dox and MDA-MB-468/Dox cells were treated with ZON and ABCC9 overexpressing vectors. The cell viability was determined by CCK-8 assays. D–G The MDA-MB-231/Dox and MDA-MB-468/Dox cells were treated with erastin, ABCC9 overexpressing vectors, and ZON. The levels of GSH (D), MDA (E), lipid ROS (F), and iron (G) were detected. **P < 0.01

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Cancer Nanotechnology

ISSN: 1868-6966

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