Fig. 5

ZON induces ferroptosis of BC cells by targeting p53. A, B The MDA-MB-231/Dox and MDA-MB-468/Dox cells were treated with erastin and ZON. The cell viability was determined by CCK-8 assays. C–F The MDA-MB-231/Dox and MDA-MB-468/Dox cells were treated with erastin, p53 shRNA, and ZON. The levels of GSH (C), MDA (D), lipid ROS (E), and iron (F) were detected. **P < 0.01