Fig. 1

The effect of paclitaxel and paclitaxel nanoparticles on the growth of tumours of cell line A2780 when grown as xenografts in mice. Mice were treated once tumours reached a mean diameter of 0.5 cm. Groups of six mice were either untreated (●), given paclitaxel (dissolved in cremophor EL, ethanol, dextrose) intravenously (▼), or paclitaxel-loaded nanoparticles orally (■) on days 0, 2, and 4. Tumour volumes (A) and body weights (B) are expressed relative to that on the day of treatment (day 0) and results are the mean±SEM of six mice